摘要
【目的】观察高血压病（essential hypertension，EH）合并2型糖尿病患者（type2 diabetes mellitus，T2DM）的心率震荡（heart rate turbulence，HRT）和心率变异（heart rate variability，HRV）的变化。【方法】EH合并T2DM者84例、EH80例，健康对照组60例，记录24h动态心电图，计算HRT的初始值（TO）和震荡斜率值（TS）以及SDNN、PNN50和LF／HF，比较三组之间的差别，分析HRT和HRV之间的相关性。【结果】EH合并T2DM和EH患者的HRT和HRV较正常对照组均有明显异常（P〈0．05），EH合并T2DM患者的TS和LF／HF较EH组明显降低（P〈0．05）；HRV的各项指标和HRT均有良好的相关性，其中PNN50与HRT相关系数最高。【结论】EH患者有显著的HRT减弱及HRV的异常，其中EH合并T2DM较单纯的EH患者更加明显，且HRT与HRV的密切相关，再次证明心脏自主神经功能异常在EH，特别是EH并T2DM中的重要作用。
[Objective] To observe the changes of heart rate turbulence （HRT） and heart rate variability （HRV） in patients with essential hypertension（EH） and type 2 diabetes mellitus（T2DM） with EH . [Methods] The total of 84 patients with T2DM with EH, 80 patients with EH and 58 control subjects were investigated . Turbulence onset（TO）, turbulence slope（TS） , SDNN, PNN50 and LF/ HF were measured by using recorded 24 hours dynamic electrocardiogram. The differences among them were compared, and the correlation between them was analyzed. [Results] All of the values of HRT and HRV were significantly different between T2DM with EH or EH group and control group （ P〈0.05）. TS and LF/ HF were significantly lower in T2DM with EH group than those of EH group （ P〈0. 05）. Good correlations were found between HRT and HRV parameters. The correlation coefficient between PNN50 and TO/TS were the highest. [Conclusion] HRT and HRV in patients with EH are significantly abnormal and they are more significant in patients with T2DM with EH than in patients with EH. And there is a strong correlation between HRT and HRV. It suggests that cardiac autonomic nerve dysfunction perhaps plays an important role in EH, especially in T2DM with EH.
出处
《医学临床研究》
CAS
2009年第6期1034-1036,共3页
Journal of Clinical Research
