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生物钟基因与心血管疾病的关系 被引量：3

The relationship between the clock gene and cardiovascular diseases
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摘要 本文对生物钟基因研究的最新进展进行了综述。重点阐述了近日钟基因通过自身的转录、翻译和调控形成近日节律的过程。介绍近日钟基因在心血管系统中的重要地位。
作者 陈晨 江舟 王正荣
机构地区 四川大学卫生部时间生物学重点实验室 四川省绵阳科学城医院
出处 《四川生理科学杂志》 2009年第2期80-83,共4页 Sichuan Journal of Physiological Sciences
基金 自然科学基金资助项目(C30871357)
关键词 生物钟 基因 心血管病 时间生物学
分类号 R54 [医药卫生—心血管疾病]
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参考文献26

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同被引文献33

  • 1Hughes M,Deharo L,Pulivarthy SR. High-resolution time course analysis of gene expression from pituitary[J].Cold Spring Harbor Symposium on Quantitative Biology,2007,(01):381-386.
  • 2Hashiramoto A,Yamane T,Tsumiyama K. Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-{alpha}[J].Journal of Immunology,2010,(03):1560-1565.
  • 3Keller M,Mazuch J,Abraham U. A circadian clock in macrophages controls inflammatory immune responses[J].Proceedings of the National Academy of Sciences(USA),2009,(50):21407-21412.
  • 4Mullenders J,Fabius AW,Madiredjo M. A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway[J].PLoS One,2009,(03):e4798.
  • 5Ozturk N,Lee JH,Gaddameedhi S. Loss of cryptochrome reduces cancer risk in p53 mutant mice[J].Proceedings of the National Academy of Sciences(USA),2009,(08):2841-2846.doi:10.1073/pnas.0813028106.
  • 6Zhang EE,Liu AC,Hirota T. A genome-wide RNAi screen for modifiers of the circadian clock in human cells[J].Cell,2009,(01):199-210.doi:10.1016/j.cell.2009.08.031.
  • 7Granda TG,Liu XH,Smaaland R. Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor[J].Federation of America Societies for Experimental Biology Journal,2005,(02):304-306.
  • 8Fu L,Pelicano H,Liu J. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo[J].Cell,2002,(01):41-50.
  • 9Gauger MA,Sancar A. Cryptochrome,circadian cycle,cell cycle checkpoints,and cancer[J].Cancer Research,2005,(15):6828-6834.
  • 10Gorbacheva VY,Kondratov RV,Zhang R. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex[J].Proceedings of the National Academy of Sciences(USA),2005,(09):3407-3412.doi:10.1073/pnas.0409897102.

引证文献3

二级引证文献7

四川生理科学杂志
2009年 第2期

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