摘要
干扰素是机体细胞对病毒感染或各种生物诱生作用反应而产生并分泌的一类具有多种生物活性的糖蛋白,具有抗病毒、抗肿瘤和免疫调节作用,其重组药物广泛应用于临床,但药物的不良反应也是较突出的问题。充分了解干扰素的不良反应是临床干扰素推广应用的重要前提。本文简要综述干扰素临床应用中出现的不良反应、产生机制、影响因素及其治疗措施。
Interferon （IFN） is a kind ofbioactive glycoprotein, which is synthesized and secreted by virus-infected or other biological-induced cells. IFN plays a significant role in inhibiting virus as well as oncoma and immunomodulation, and has an extensive clinical application. However, the adverse reactions of IFN is also a problem exerted. Accordingly, a better comprehension for IFN is prerequisite for its application. In this review, the adverse reactions of IFN and its mechanisms, influential factors, as well as management were summarized.
出处
《世界临床药物》
CAS
2009年第6期334-338,共5页
World Clinical Drug
关键词
干扰素
不良反应
肝炎
病毒性
处理
interferon
adverse reaction
hepatitis
viral
management
