摘要
目的比较ＩｇＡ肾病（ＩｇＡＮ）肾组织中乙型肝炎病毒抗原（ＨＢＡｇ）阳性和阴性患者的临床与病理特点。方法收集经免疫组化检测证实的肾组织ＨＢＶ抗原阳性组２６例和阴性组５９例ＩｇＡＮ患者的临床和病理及随访资料。结果与阴性组相比，阳性组肾病综合征者多见，血红蛋白、血ＩｇＡ水平和肌酐清除率显著下降，免疫荧光以ＩｇＡ＋ＩｇＧ＋ＩｇＭ型者多见，肾组织病理损害以Ⅳ级为多，肾小球硬化、肾小管病变、间质炎症和纤维化程度均显著严重。两组在临床表现、实验室检查、病理改变及预后方面均有显著性差异，阳性组临床病理改变更严重、预后更差。结论两组是性质相差较大的病变。
Objective To compare the clinicopathologic changes between IgAN with HBAg positive group(GⅠ) in renal tissue and the negative group(GⅡ)Methods 26 cases of IgAN with positive and 59 cases with negative HBAg detected by immunohistochemical techniques in renal tissue were collected and followed upResults The nephrotic syndrome IgA+IgG+IgM pattern in immunofluorescent deposites and grade Ⅳ of renal lesion were more frequent in the GI than theGII;the level of hemoglobin、serum IgA and creatinine clearance rate were significantly lower,24h proteinuria was higher in the GI than the GII;the degree of sclerosed glomeruli,renal tubular lesion,interstitial inflammation and fibrosis was significantly higher in the GI than the GIIThere were two patients entered the uremic period in the GI during the follow-upWhen comparing the clinical manifestation、laboratory test、the pathologic changes and prognosis ,there were significantly difference between the GI and GII,the GI was more obvious and severeConclusion These two groups may be two disease entities,antiviral treatment to the GI was very important
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1998年第3期167-170,共4页
Chinese Journal of Nephrology
