摘要
报告２２例系膜性ＩｇＭ肾病（ＩｇＭＮ），占同期原发性肾小球疾病（肾活检证实）总数的１３．９２％。临床表现为肾病综合征（ＮＳ）１５例，单纯性蛋白尿５例，蛋白尿伴镜下血尿２例。血清ＩｇＭ明显升高者１６例，其中１例最高达４．０９ｇ／Ｌ。病理检查全部病例肾小球系膜区以ＩｇＭ沉积为主，其中２０例为系膜增生性肾炎，２例为微小病变。１５例ＮＳ患者经激素或激素＋ＣＴＸ治疗后，完全缓解１２例，部分缓解３例，复发６例。２例ＮＳ伴有急性肾功能衰竭患者。
The incidence of IgMN among primary glomeulonephritis was 13.92%(22/196),15 patients presented with nephritis syndrome,5 with protienuria,2 with protienuria and microscopic hematuria.Two patients presented acut renal failure(ARF).All cases had diffuse IgM deposition in the mesangial area,20 cases with varying degrees of mesangial proliferation,2 with minimal change dieases,7 with glomeular sclerosis or with tubular atrophy, 1 with interstitial fibrosis and 3 with interstitial mononuclear cell infiltration.Serum IgM level was significantly elevated in 16 patients,but no correlation was found between its concentration and the intensity of fluorescence of IgM deposited in mesangium.After treatment with corticosteroids(P)or corticosteroids and cyclophosphamide,12(12/15)NS patients were completely remitted in which 6 were relapsed,3 had no response.After treatment with heamodialysis,the renal founction of 2 patients with ARF were normal.
出处
《北京医学》
CAS
北大核心
1998年第3期162-164,共3页
Beijing Medical Journal
