摘要
目的为了研究瘢痕疙瘩是否与血清铜蓝蛋白（Ｃｅｒｕｌｏｐｌａｓｍｉｎ，ＣＰ）浓度有关。方法利用间接ＥＬＩＳＡ（酶联免疫吸附试验）的方法，初步探讨了血清ＣＰ的ＥＬＩＳＡ测定方法及在瘢痕疙瘩治疗中的应用。结果瘢痕疙瘩组ＣＰ含量明显增高，与正常对照组比较差别有显著意义（Ｐ＜０．０１）。祛炎舒松Ａ治疗后血清ＣＰ含量较瘢痕疙瘩组低（Ｐ＜０．０５）。结论瘢痕疙瘩病人血清ＣＰ含量增高，祛炎松Ａ治疗后血清ＣＰ下降。
Objective In order to study the keloid is related with the level of serum concentration of CP (Ceruloplasmin). Fibrotic disease such as silicosis sclerederma are related with the level of serum concentration of CP.Method This preliminary research was carried out by the method of indirect ELISA (enzyme linked immunosorbent assay). We investigated the method of measuring CP in serum by ELISA and estimated the value in keloid treating.Result The level of CP is significantly higher than that of the control group (P<0.01). The CP level of the group treated with triamicinolone is lower than that of the keloid group (P<0.05).Conclusion The results show that the serum CP level is higher in keloid patients. After treated with triamcinolone, the CP concentration becomes lower, so the serum concentration of CP is an important factor can not be ignored in the keloid treating. It can be used as one of criteria to judge if a person with keloid tendency as well as to evaluate the effect of treatment.
