6Christman BW, McPherson CD, Newman JH, et al. An imbalance between the excretion of thromboxane and pros- tacyclin metabolites in pulmonary hypertension[ J]. N En- gl J Med,1992,327:70 -75.
7Giaid A, Yanagisawa M, Langleben D, et al Expression of endothelin-1 in the lungs of patients with pulmonary hy- pertension[ J ]. N Engl J Med, 1993,328 ( 24 ) : 1732 - 1739.
8Steward D J, Levy RD, Cernacek P. Increased plasma en- dothelin-1 in pulmonary hypertension marker or mediator of disease? [ J ]. Am Intern Med, 1991,114:464 - 469.
9Pietra GG, Capron F, Stewart S, et al. Pathologic assess- ment of vasculopathies in pulmonary hypertension [ J ]. J Am Coli Cardio1,2004,43( 12 Suppl S) :25S- 32S.
10Rubens C, Ewert R, Halank M, et al. Big endothelin-I and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension [ J ]. Chest, 2001,120 (5) : 1562 - 1569.
