摘要
目的探讨住院少年儿童精神障碍患者精神药物应用状况。方法采用分层整群抽样的方法，抽取121例在我院住院的少年儿童精神病患者的临床资料进行回顾性分析。结果男童59例（48．76％），女童62例（51．24％）；年龄集中于13a～14a（69例，57．02％）；诊断：精神分裂症37例（30．58％），心境障碍18例（14．88％），精神发育迟滞13例（10．74％），癫痫12例（9．92％）。应用药物频度依次为利培酮（38．84％）、地西泮（24．79％）、氯氮平（21．48％）、丙戊酸钠（17．36%）；单一用药21例（17．35％），2种联用53例（43．81％），≥3种46例（38．02％）；31．40％联用苯海索，药物剂量均在正常范围。精神药物副反应发生频度依次为体重增加21．67％、口干15．00％、嗜睡14．17％。结论少年儿童精神障碍临床治疗中注重用药安全，联合用药较多，非典型抗精神药物及新型抗抑郁药物应用增多。
Objective To investigate the psychotropic drugs use status in children with mental disorders. Methods Clinical data of selected 121 children with mental disorders hospitalized in our hospital using stratified cluster sampling were retrospectively analyzed. Results Among all the patients, 59 were male （48. 76%）and 62 female（51.24%）. Sixty-nine patients（57.02%）were aged 13 to 14 years. Thirty-seven patients（30.58%）were diagnosed as schizophrenia,then 18 as mood disorder（14.88%）, 13 as mental retardation（10. 74%）and 12 as epilepsy（9.92%）. The most use drug was risperidone（38.84%）, then diazepam（24.79%, clozapine（21.48%） and valproate sodium（17.36%）. Twenty-one（17.35%） used psychiatry drugs only, 53（43.81%） combined two kinds of grug and 46（38.02%） did ≥three, 31.40% combined trihexyphenidyl, and drug doses were in normal range. The emerged frequency of adverse reactions were in turn weight gain（21.67%）, dry mouth（15.00%） and drowsiness（14. 17%）. Conclusion The medication safety is emphasized, combined medication more, use of atypical antipsychotics and neotype antidepressant drugs increased in clinical treatment of child mental disorders.
出处
《临床心身疾病杂志》
CAS
2009年第3期239-241,共3页
Journal of Clinical Psychosomatic Diseases
