摘要
目的探讨新一代质子泵抑制剂埃索美拉唑对反流性食管炎(RE)的临床疗效。方法将108例经胃镜证实的RE患者随机分为两组,A组58例,给予埃索美拉唑40 mg,每日1次;B组50例,予以奥美拉唑20 mg,每日2次,两组疗程均为8周。两组均同时加用促动力药莫沙比利,分别于治疗4、6、8周后记录烧心、反酸和胸骨后灼痛等症状记分,判断疗效。并于8周后复查胃镜,观察胃镜下愈合率。结果两组治疗均有效,而A组A级、B级食管炎疗效、烧心症状改善均优于B组。结论埃索美拉唑治疗RE疗效确切。
Objective To investigate the clinical effect of new proton pump inhibitor esomeprazole on reflux esophagitis. Methods 108 patients with reflux esophagitis diagnosed by endoscopy were randomly divided into group A （n= 58） and group B（n= 50）. Group A was treat with esomeprazole. Group B was treated with omeprazole. All patients add- ed mosapride. The effects were evaluated with symptoms and gastroscop. Results After 8 weeks treatment, the total symptom apparent effect rate was 86.2% in group A and 56. 0% in group B （P〈0. 05%） . The total symptom improvement rate was 96.6% in group A and 73.0% in group B（P〈0.05）. There were significant differences in endoscope amelioration between the two groups. Conclusion Esomepraxole is effective in treatment of reflux esophagitis.
出处
《西部医学》
2009年第6期962-963,966,共3页
Medical Journal of West China
