摘要
将对羟乙氧基苯甲酸分别与己二酰氯、癸二酰氯和对苯二甲酰氯反应，制备了含酯键的二羧酸．经熔融缩聚，合成了主链含酯键的新型聚酯酸酐．通过１ＨＮＭＲ、ＩＲ及元素分析对单体及聚酯酸酐的结构进行了表征．研究了聚酯酸酐的体外降解和药物释放性能，其降解速率和释药速率次序为：聚４，４′－（己二酰氧二乙氧基）双对苯二甲酸＞聚４，４′－（癸二酰氧二乙氧基）双对苯二甲酸＞聚４，４′－（对苯二甲酰氧二乙氧基）双对苯二甲酸．
? (Adipyldioxyethyoxy)dibenzoic acid(1a), 4,4′ (sebacoyldioxyethyoxy)dibenzoic acid(1b) and 4,4′ (benzoyldioxyethyoxy)dibenzoic acid(1c) were synthesized and converted into mixed anhydrides by the reaction with acetic anhydride. Poly(ester anhydride)s 2a, 2b and 2c were yielded by subsequent melt polycondensation. Their chemical structures were confirmed by 1H NMR, IR, UV and elemental analysis. In vitro degradation of poly(ester anhydride)s in phosphate buffer solution at 37 ℃ was determined. Drug release profile of Ciprofloxacin was also studied.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第5期813-816,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
