摘要
本实验用HPLC-ECD方法测定SHR和WKY大鼠的中枢单胺神经递质。在被测的六个脑区中(额叶皮质、尾状核、下丘脑前部、下丘脑后部、海马和延髓)发现NE和5-HT呈普遗下降趋势;DA在6月龄SHR尾状核升高明显;SHR的下丘脑和尾状核从3月龄到6月龄呈现一个递质的增减变化过程。实验提示:单胺神经递质在原发性高血压的发生和维持机制中起重要作用,下丘脑和尾状核是二个重要的递质血压相关区,尤其是尾状核的DA递质。
Using HPLC-EC (High performance Liquid Chromatography with Electrochemical Detector), the monoamine levels in SHR in the 3rd and 6th month of age and age matched WKY were measured. Six regions of the brain were examined on each animal.The results show: in most regions of SHR, both 3rd and 6th month groups, the NE and 5-HT levels decreased significantly; but those in caudate nucleus of SHR in 6th month groups, the DA level increased remarkably. These results support the idea that the change of monoamine levels are related to the development and maintenance of Hypertension and the caudate nucleus may play an Important role in regulation of blood pressure.
出处
《解剖学杂志》
CAS
CSCD
北大核心
1990年第4期301-304,共4页
Chinese Journal of Anatomy
