摘要
本实验利用来亨鸡胚,于孵育第3天,从其气室注入0.2 ml不同浓度的氯化铝(AlCl_3)水溶液,测出其对鸡胚的最大容许剂量为1.708μmol/卵,最小致死量为2.25μmol/卵,绝对致死量为35.34μmol/卵,半数致死量为8.09μmol/卵。胚胎死亡率随药物剂量增大而上升,有明显的剂量-反应依赖关系。本实验表明,AlCl_2对鸡胚的发育速度有抑制和明显的致畸作用。
The toxic and teratogenic effect of AlCl_3 on leghorn chick embryos were studied. Different concentrations of AlCl_3 dissolved in redistilled water were injected into the air sac of the eggs (0.2 ml per egg) on the third day of incubation. It was identified that the maximal permissible dosage was 1.708 μmol/egg, the minimal lethal dosage was 2.25 μmol/egg, the absolute lethal dose was 35.34 μmol/egg, and LD_(50) was 8.09 μmol/egg. The mortality of the embryos raised with the increase of the dose of AlCl_3. AlCl_3 also retarded the development of chick embryos and showed apparent tetratogenic effects.
出处
《解剖学报》
CAS
CSCD
北大核心
1990年第1期102-106,共5页
Acta Anatomica Sinica
关键词
氯化铝
毒性
致畸作用
环境污染
Toxicity
Teratogenic effect
Environment pollution
Aluminium chloride
Chick embryos
