摘要
采用顺铂乙基纤维素微球(CDDPmc)作肝动脉注射,测定了新西兰兔外周血液和肝组织中的铂浓度,并观察了对大鼠移植性肝癌的疗效。肝动脉注射CDDPmc后,外周血中铂浓度上升幅度小并维持在低水平,肝组织中铂浓度则长时间保持在较高水平;而肝动脉注射常规剂型顺铂后,外周血中出现一过性铂浓度高峰,肝组织中高铂浓度维持时间短暂。肝癌大鼠接受肝动脉注射CDDPmc后,肿瘤生长受到显著抑制,肿块发生广泛坏死,动物生存时间得到显著延长,其疗效明显优于肝动脉注射常规剂型顺铂和空白乙基纤维素微球。本实验结果说明,肝动脉注射CDDPmc减少了药物进入循环血液的量,保持了治疗局部持久的药物高浓度,提高了肝动脉化疗疗效。
Study of in vivo release and tumoricidal effect of cisplatin microcapsules (CDDPmc) alter hepatic arterial infusion was conducted in New Zealand rabbits and rats with implanted liver tumor.In rabbits infused with CDDPmc,the platinum concentration,as measured at different time intervals,was found 'to be much lower in circulating blood,while it was maintained at high level for a significantly longer time in hepatic tissue,when compared to that in rabbits infused with conventional CDDP.A superior therapeutic effect on rat liver tumor of CDDPmc to conventional CDDP and placebo ethylcellulose microcapsules after hepatic arterial infusion was observed with a significantly lower tumor growth ratio,more extensive tumor necrosis and longer survival time.It could be concluded from our findings that hepatic arterial infusion of CDDPmc produced a low drug concentration in the blood,but with prolonged high drug concentration in target tissue,and as a result,it exerted a superior antitumor effect with low side effect.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1990年第5期324-327,共4页
Medical Journal of Chinese People's Liberation Army
关键词
肝动脉
化疗栓塞
顺铂
肝癌
Hepatic artery Chemoembolization Cisplatin Liver tumor
