摘要
报告应用特异性肺癌转移因子(SPTF)对肺癌患者进行免疫治疗的效果观察。肺癌患者50例分为两组,一组化疗加用SPTF(35例),一组单纯化疗作为对照(15例)。结果化疗反应SPTF组比对照组明显减轻。用OKT单克隆抗体检测外周血T淋巴细胞亚群,发现SPTF组治疗前后OKT_4、OKT_8、OKT_4/OKT_8比值差别非常显著(P<0.001),对照组治疗前后差别不显著(P≥0.05)。以上结果提示SPTF能提高肺癌患者的免疫功能,对肺癌的转归发生良好作用。本组采用的SPTF具有取材来源充足,有抗原特异活性及无毒副作用等优点。
A series of 50 patients with lung carcinoma were studied to evaluate the clinical and immune effects of specific transfer factor (SPTF).The SPTF group (n=35) received both chemotherapy and SPTP treatment,which was administered by intramuscular injection 2ml (2 unit) twice a week for 4 weeks.The control group (n=15) received only chemotherapy.During the treatment the sideeffects of chemotherapy in the SPTF group were significantly lower than that of the control group.Peripheral blood T-lymphocyte subsets were determined by OKT McAb.There were significant differences in OKT4,OKT8,OKT4/OKT8 ratio before and after the administration of SPTF (P<0.001).There were no differences in the control group.The results of the study suggest that the specific immunothe-rapy by means of SPTF can increase the immune competence of patients with lung cancer.SPTF has been proved to have antigen-specific activities,without side effects.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1990年第3期198-200,共3页
Medical Journal of Chinese People's Liberation Army
关键词
肺癌
转移因子
免疫疗法
Specific transfer factor of lung carcinoma Lung carcinoma Immunotherapy
