摘要
目的：研究ｂｃｌ－２蛋白在宫颈癌中的表达。方法：采用免疫组化ＡＢＣ法对１０例正常宫颈组织，１６例慢性宫颈炎，１２３例宫颈鳞癌进行了ｂｃｌ－２基因蛋白表达测定。结果：宫颈鳞癌中ｂｃｌ－２阳性表达（５５．２９％）显著高于宫颈正常及炎症组织（１８．７５％）（Ｐ＜０．０１），且ｂｃｌ－２表达随临床期别升高而降低。其中０期（３／３），Ⅰ期（８４．６２％），Ⅱ期（７４．５１％），显著高于Ⅲ期（２８．５７％）（Ｐ＜０．０５）。ｂｃｌ－２蛋白表达与宫颈癌组织分化程度及存活率呈正相关。结论：ｂｃｌ－２基因变化在宫颈癌发生和发展中起重要作用，其过度表达多见于宫颈癌早期，且提示肿瘤较好的临床行为及预后。
Although expression of bcl2 oncoprotein has been found in a number of human malignancies, but it has never been reported on cervical carcinoma. We detected the expression of bcl2 in 10 normal cervical tissues,16 chronic cervicitis and 123 cervical squamous carcinomas by ABC immunohistochemical staining. The positive rate of bcl2 expression was significantly higher in carcinomas (55.29%) than those in normals and cervicitis (18.78%, P<0.01). In cervical carcinoma,expression of bcl2 decreased with the increased clinical stage,and those in stage 0 (3/3), stage I (84.64%), and stage II (74.51%) were higher than that in stage III (28.57%, P<0.05). Expression of bcl2 showed a positive correlation to the differentiation of the tumor and the survival of the patients.The results suggest that bcl2 expression plays an important role in development and malignant change of cervical carcinoma and that overexpression of bcl2 is characteristic of the early phase and that its expression is associated with a better clinical course.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第5期334-337,共4页
Chinese Journal of Clinical Oncology
基金
天津市科委自然科学基金
关键词
子宫肿瘤
宫颈癌
细胞凋亡
BCL-2蛋白
bcl2 oncoprotein Cervical carcinoma Immunohistochemistry Apoptosis
