摘要
本研究旨在通过三氯醋酸对金黄地鼠颊囊粘膜作用的研究，了解其可能引起粘膜损伤的性质。为用于临床治疗提供理论依据。本试验是以金黄地鼠作为试验动物，20％三氯醋酸作为涂布试剂，手术后不同时期处死动物，对标本行光镜和透射电镜观察。结果显示：20％三氯醋酸可引起粘膜的坏死脱落，形成溃疡，坏死区由新生上皮替代，并且出现明显的纤维组织增生，提示：三氯醋酸用于口腔颌面部上皮性囊肿治疗，可能因上皮破坏治愈囊肿或降低其复发率。
The purpose of this study wsa to explore the mechanism of injury of oral mucosa caused by 20% trichloroacetic acid (TCA). The method of this study was to spread 20% TCA on the buccal pouch mucosa of hamster and animals were sacrificed at different time postoperatively,The spicemens were studied by light microscopy and transmission electron microscopy. The results as follows: 20%TCA caused epithelial necrosis and ulcer formation. At 3 weeks postoperatively. buccal pouches were reepithelized and reaction of enzyme histochemistry reappeared and there were an apparent increase in the amount of collagen and fibroblast. The results suggest: 20% TCA is a kind of cauterizing agent.Which can cause necrosis of mucosa. If epithelial cysts were treated with 20% TCA. It's possible to cure the cysts or decrease their recurrence.
出处
《临床口腔医学杂志》
1998年第2期99-100,共2页
Journal of Clinical Stomatology
关键词
三氯醋酸
颊囊
口腔颌面部囊肿
治疗
20% trichloroacteic acid buccal pouch hamster histopathology
