摘要
目的探讨经不同给药途径时在肿瘤组织内抗癌剂药物浓度的聚积性。方法对２０例可切除进展期胃癌，用卡铂３００ｍｇ／ｍ２分别腹腔、静脉给药，注射后１６０～１８０分钟取腹腔液、门静脉及外周血，２４０～２７０分钟取癌组织、癌旁正常组织、大网膜、腹膜及转移阴性淋巴结，应用高效液相色谱法（ＨＰＬＣ）测定总铂浓度。结果与静脉给药组相比，腹腔给药各组织内聚积较高的药物浓度，其中腹膜浓度最高，超出静脉给药组近４倍，癌组织内含量高于正常组织。腹腔液、门静脉、外周血分别超出静脉给药组１３、３及１５倍。结论腹腔化疗不仅提高了腹腔、门静脉和肝脏药物浓度，而且使药物在腹膜、肿瘤组织内聚积较高的浓度，延长了药物的作用时间，对于防止腹膜、肝转移，控制医源性扩散，改善临床病期有一定意义。
Objective To find out the accumulation of anticancer drugs in tissues of tumor patients by different way of administration. Methods 300 mg/m2 carboplatin was administrated by intraperitoneally (IP) and intravenously (IV) to 20 patients with resectable but advanced gastric cancer. 160～180 minutes after injection, peritoneal fluid, blood of portal vein and peripheral blood were taken. 240～270 minutes later, cancer tissue, normal tissue, greater omentum, peritoneum and lymph nodes without metastasis were collected. Total carboplatin concentrations were measured with high performance liquid chromatography (HPLC). Results High concentrations of the drug were present in all the tissues with IP than with IV administation. The concentration of carboplatin in peritoneum was the highest, being 4 times higher than that with IV administration. The concentration in cancer tissue was higher than that in normal tissue. The concentration in peritoneal fluid, blood of portal vein and peripheral blood after IP administration were 13, 3, 1.5 times higher than that with IV administration respectively. Conclusion Intraperitoneal chemotherapy not only increase the concentrations of drugs in peritoneal cavity portal vein and liver, but also yield high concentrations in peritoneum and tumor tissues, prolong the effective time of drugs. This property is important for prevention of peritoneal and hepatic metastasis, control of iatrogenic diffusion and improvement clinical stage.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1998年第6期387-389,共3页
Chinese Journal of Internal Medicine
关键词
卡铂
胃肿瘤
药物疗法
HPLC
Carboplatin Chemotherapy, adjuvant Gastrointestinal neoplasms
