摘要
目的 研究CD44V6在鳞状细胞癌、基底细胞癌和恶性黑素瘤的表达。方法 免疫组织化学对石蜡包埋组织标本进行检测。结果 1 0例鳞状细胞癌CD44V6膜表达阳性 ,且随癌细胞分化程度降低CD44V6表达下调。 1 0例基底细胞癌和 8例恶性黑素瘤不表达CD44V6。
Objective To study the expression of CD44V6 in human epidermal tumours and malignant melanoma. Methods The expression of CD44V6 was detected by an immunohistochemical technique in squamous cell carcinoma(SCC), basal cell carcinoma(BCC) and malignant melanoma(MM). Results CD44V6 was expressed on the membrane of tumour cells of 10 patients with SCC, and there was downregulation of CD44V6 expression which along with the decrease of differentiation of SCC tumour cells. Tumour cells of 8 patients with MM and 10 patients with BCC did not express CD44V6. Conclusion Our findings suggest that CD44V6 expression is correlated with the types of skin tumours.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1998年第3期176-177,共2页
Chinese Journal of Dermatology
关键词
CD44V6
鳞状细胞瘤
基底细胞瘤
黑素瘤
CD44V6 Squamous cell carcinoma Basal cell carcinoma Malignant melanoma
