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冠心病患者体内血小板活化状态的检测 被引量:3

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摘要 目的:研究冠心病患者体内的血小板活化状态,建立能准确地反映体内血小板活化水平的实验室方法。方法:测定15例健康志愿者及60例冠心病患者血浆11-去氢-血栓烷B2(11-DH-TXB2)浓度,同时采用流式细胞术(FCM)和放射免疫法(RIA)测定其血小板GMP-140水平。结果:患病组与正常对照组比较,其11-DH-TXB2浓度明显增高(P<0.01),患病组各组间也有高度显著性差异(P<0.01);用FCM检测GMP-140结果与11-DH-TXB2变化基本一致;而放免法反映血小板活化状态却不如前两种方法明显。结论:11-DH-TXB2具有稳定的生物学特性,流式细胞术检测血小板GMP-140特异性强,两者均能准确地反映体内血小板的活化程度。
出处 《中国现代医学杂志》 CAS CSCD 1998年第5期22-23,共2页 China Journal of Modern Medicine
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  • 1Funheer R. moddtrman P. W. Veldman H. et al.Detection of platelet activation with monodonal antibodies and flow cytometry. Transfusion . 1990
  • 2Sanford J,Shattil,Michall Cunningham,et al.Detetion of activated platelets in whole blood uning activation-dependent monoclonal antibodies and flow cytometry. Blood . 1987
  • 3Abrams C.Immunelogical detection of activated platelets in clinical disorders. Thrombosis and Haemostasis . 1991
  • 4Tschope D. Schultheib H. P. Kolarov P,et al.Platelet membrane activation markers are predictive for increased risk of acute ischemic events after PTCA. Circulation . 1993
  • 5McEver RP.Seletions: Novel receptors that mediate leukocyte adherion during inflammation. Thrombosis and Haemostasis . 1991
  • 6Nurden AT,Macchil,Bihour C,et al.Markers of platelets activation in coronery heart disease patient. European Journal of Clinical Investigation . 1994
  • 7Groffrey I,Johnston,Elaine B,et al.Heterogeneity of platelet secretion in response to thrombin demonstrated by fluorecerce flow cytometry. Blood . 1987
  • 8Chesebro JH,Lam JYT,Badimon L,et al.Restenosis after arterial angioplasty: a hemorheologie responre to injuny. The American Journal of Cardiology . 1987
  • 9McEver RP.GMP-140: a receptor for neutrophils and monocytes on actived platelets and endotheliums. Journal of Cellular Biochemistry . 1991

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