摘要
目的:采用不同剂量沐舒坦治疗小儿急性肺损伤,评价其疗效。方法:选择2004年1月～2007年12月收住我院的急性肺损伤患儿116例,随机分为3组,即大剂量沐舒坦[30mg/(kg·d)]组、常规剂量[5mg/(kg·d)]组及对照组,监测PaO2、PaO2/FiO2及临床转归。结果:各组治疗后PaO2及PaO2/FiO2较治疗前明显好转,治疗3d时大剂量组PaO2及氧合指数明显高于对照组和常规剂量组(均P<0.05)。经治疗,进展到ARDS者大剂量组明显少于常规剂量组及对照组(χ2=7.6,P<0.05)。剔除ARDS病例后,大剂量组PaO2/FiO2恢复到300mmHg以上时间明显短于常规剂量组和对照组(F=11.5,P<0.001)。结论:机械通气治疗基础上加用大剂量沐舒坦能提高小儿急性肺损伤的疗效,降低ARDS发生率。
Objective： To investigate the clinical value of taking different doses Mucosolvin to treat children＇s acute injury of lungs. Methods： 116 children who suffered from acute injury of lungs in our hospital from January 2004 to December 2007 were chosen.And they were divided into 3 groups randomly, the first group was treated by a big dose of Mucosolvin, another group were treated by normal dose, and a control group. Monitoring PaO2 and PaO2/FiO2 and clinical results.Results： Duing to the observation of PaO2 and PaO2/FiO2, both of the treatment groups had got better than before, on the third day during the treatment, PaO2 and Oxygenation index in the group treated by big dose （the first group） were much higher than the other two groups （P〈0.05）, while the possibility to become ARDS in the first group was much less than the other two （Х^2 =7.6,P〈0.05）.Apart from the cases with ARDS, the time that the PaO2/FiO2 in the first group recovered up to 300 mm Hg was also less than the other two groups （F=11.5 ,P〈0.001 ）.Conclusion： Being treated by a big dose of Mucosolvin at the foundation of mechanical ventilation can raise the clinical effect and reduce the occurring rate of children＇s ARDS.
出处
《中国医药导报》
CAS
2009年第16期103-104,共2页
China Medical Herald
关键词
急性肺损伤
沐舒坦
小儿
Acute injury of lungs
Mucosolvin
Children
