摘要
目的:研究天麻粉(粒度为200～350目)制成的片剂对小鼠睡眠的改善作用。方法:健康雄性小鼠每天经口灌胃给予天麻粉片,并按所给剂量分成3组(0.25g/kg体重剂量组、0.50g/kg体重剂量组、1.50g/kg体重剂量组),观察直接睡眠作用;连续给予30d后进行延长戊巴比妥钠睡眠时间试验、戊巴比妥钠阈下剂量催眠试验和巴比妥钠睡眠潜伏期试验。结果:天麻粉片对各剂量组无直接睡眠作用;0.5g/kg体重剂量组、1.5g/kg体重剂量组能延长戊巴比妥钠诱导的小鼠睡眠时间(P<0.05、P<0.01);1.5g/kg体重剂量组能缩短巴比妥钠的睡眠潜伏期(P<0.01)。结论:天麻粉片具有改善睡眠功能的作用。
Objective： To investigate the effect of Gastrodia tablets on sleep in mice. Methods： Healthy male mice were divided into three groups and orally administered with the Gastrodina Tablets at daily doses of 0.25 g/kg, 0.50 g/kg, and 1.50 g/kg, respectively, and the drug＇s direct effects on sleep was observed. After 30 days of consecutive administration, the sleep-extending test with sodium pentobarbital, the sleep-producing test with subthreshold dose of sodium barbital, and the incubation period test with sodium pentobarbital were conducted. Results： GastrodiaTablets had no direct effect on sleep. The sleep time induced by sodium pentobarbital was significantly prolonged in the Gastrodia Tablets 0.50 g/kg group and 1.50 g/kg group（P〈0.05, P〈0.01）. The incubation period induced by sodium barbital was significantly decreased in the 1. 50 g/kg group （P〈0.01）. Conclusion： The Gastrodia Tables can improve the sleep quality of mice.
出处
《中国医药导报》
CAS
2009年第16期39-41,共3页
China Medical Herald
关键词
天麻粉片剂
睡眠改善
实验研究
Gastrodina Tablets
Sleep quality improvement
Experimental study
