摘要
目的:观察缬沙坦对慢性肾病继发高血压的降压作用。方法:96例肾性高血压患者随机分为两组,治疗组64例,应用缬沙坦;对照组32例,应用依那普利;观察两组用药前及用药8周后血钾、血钠、血氯、24h尿蛋白定量、血尿素氮、肌酐及血促红细胞生成素情况,应用χ2检验比较上述各因素用药前后的变化。结果:应用缬沙坦8周后,血钾、血钠、血氯、血尿素氮、肌酐及血促红细胞生成素无明显变化;24h尿蛋白定量减少,有显著性差异。结论:缬沙坦对慢性肾病继发高血压的降压作用中对血钾、血钠、血氯、血尿素氮、肌酐及血促红细胞生成素无明显影响,24h尿蛋白定量明显减少。
Objective： To observe the antihypertensive effect of Valsartan on chronic renal hypertension. Methods： 96 cases of patients with renal hypertension were randomly divided into two groups, 64 cases in treatment group were treated with Valsartan, and 32 cases in control group were treated with Enalapril, then plasma K^＋, Na^＋, Cl^-, 24 h urine protein, BUN, Scr and EPO before administering drugs and 8 weeks after administering drugs were detected. Results： No significant difference in plasma K^＋, Na^＋, Cl^-, BUN, Scr or EPO was observed, and a significant difference was shown in 24 h urine protein. Conclusion： Vaisartan has no significant influence on plasma K^＋, Na^＋, Cl^-, BUN, Scr and EPO of patients with renal hypertention, but the 24 h urine protein is obviously decreased.
出处
《中国医药导报》
CAS
2009年第16期12-13,共2页
China Medical Herald
关键词
缬沙坦
肾性高血压
肾功能
Valsartan
Renal hypertension
Kidney function
