摘要
目的:探讨高强度聚焦超声(high intensity focused ultrasound,HIFU)治疗对胰腺癌患者外周血免疫细胞的影响。方法:对39例原发性胰腺癌患者进行HIFU治疗,观察疗效;分别取治疗前和治疗后4周的外周血2mL,检测T细胞亚群CD4、CD8、CD4/CD8及自然杀伤(naturalkiller,NK)细胞的变化。结果:39例胰腺癌患者经HIFU治疗后的完全缓解率为10.26%(4/39),部分缓解率为76.92%(30/39),有效率达87.18%(34/39),卡氏功能状态量表(Karnofsky performance status,KPS)评分明显提高,与治疗前相比差异有统计学意义(P<0.05)。治疗后NK细胞百分数、CD4T细胞百分数和CD4/CD8比值均较治疗前明显提高,CD8T细胞百分数下降,差异均有统计学意义(P<0.05)。结论:应用HIFU治疗原发性胰腺癌安全有效,并能提高患者的细胞免疫功能。
Objective： To investigate the effect of high intensity focused ultrasound （HIFU） treatment on immune cells in peripheral blood of patients with pancreatic carcinoma. Methods： Thirty-nine patients with pancreatic carcinoma were treated with HIFU and the clinical efficacy was observed. This study collected 2 mL of peripheral venous blood and examine the percentage of natural killer cells and T-lymphocyte subsets CD4, CD8, and CD4/CD8 before and four weeks after HIFU treatment.Results：The complete response rate was 10.26% （4/39） and partial response rate was 76.92% （30/39） in 39 cases of patients with pancreatic carcinoma after HIFU treatment. The effective rate was 87.18%（34/39）. Karnofsky performance status （KPS） score was significantly increased compared with those before treatment （P〈0.05）. The percentage of natural killer cells and CD4 cells and CD4/CD8 were significantly elevated after treatment and the percentage of CD8 cells were significantly decreased. The difference was significant （P〈0.05）. Conclusion：HIFU was safe and effective in the treatment of patients with primary pancreatic carcinoma and increased the cell immune function of patients.
出处
《肿瘤》
CAS
CSCD
北大核心
2009年第5期490-492,共3页
Tumor
关键词
胰腺肿瘤
超声
高强聚焦
T淋巴细胞亚群
杀伤细胞
天然
Pancreatic-neoplasma
Ultrasound,high-intensity focused
T-lymphocyte subsets
Killer cells,natural
