摘要
目的探讨肝炎后肝硬化病人血清甘氨胆酸（ＣＧ）值对肝硬化进展和预后的临床意义。方法１１３例肝炎后肝硬化患者按Ｃｈｉｌｄ分级，分为Ａ，Ｂ，Ｃ三组，采用放免法测ＣＧ值，各组数据经正态性检验呈非正态分布，故应用ＳＡＳ软件进行多样本秩和检验和相关统计。结果血清ＣＧ值随Ｃｈｉｌｄ分级加重呈递增现象，各组血清ＣＧ值之间有非常显著性差异（χ２＝４８．９０２０，Ｐ＜０．０００１）；血清ＣＧ与白蛋白呈负相关（ｒ＝－０．４７３６，Ｐ＜０．０００１），与总胆红素和凝血酶原时间呈正相关（ｒ＝０．４１７６，Ｐ＜０．０００１和ｒ＝０．３５１８，Ｐ＜０．００１）。结论血ＣＧ可作为一个估计肝硬化进展和预后的敏感指标，其敏感性较白蛋白。
Objective To evaluate the clinical significance of serum CG in the progress and prognosis of patients with posthepatic cirrhosis. Methods The 113 patients of posthepatic cirrhosis were divided into three groups according to Child A,B,C.Serum CG levels were detected by using radioimmunoassay.The data from three groups showed abnormal distribution through normal testing,so rank sum test and related statistic were done using SAS software. Results The value of serum CG were increasing with Child degree A,B,C and were significantly differente (χ 2=48.902 0, P <0.000 1).The relation between CG and albumin was negative ( r =-0.473 6, P <0.000 1) and that between CG and total bilirubin or prothrombin time was positive ( r =0.417 6, P <0.000 1 and r =0.351 8, P <0.000 1,representive). Conclusion Serum CG levels as a index to estimate progress and pregnosis of hepatic cirrhosis are more sensitive than that of albumin,total bilirubin and prothrombin time.
出处
《铁道医学》
1998年第3期162-163,共2页
Railway Medical Journal
