摘要
较异丙酚与硫贲妥钠两组麻醉方法对血压、心率、心率与收缩压乘积（ＲＰＰ）、血浆皮质醇的影响程度。方法２０例ＡＳＡⅠ级成年病人，分别以异丙酚诱导维持（ｎ＝１０），硫贲妥钠诱导、吸入氨氟醚维持（ｎ＝１０），观察支撑喉镜声带息肉摘除术诱导前、插管前后、置支撑喉镜前后、术中及拔管前后的心率、血压、ＲＰＰ变化及术前、术后血浆皮质醇变化。结果置支撑喉镜后异丙酚组较硫贲妥钠组心率明显下降（Ｐ＜０．０５）；术后硫贲妥钠组血浆皮质醇浓度明显高于异丙酚组（Ｐ＜０．０１）。结论异丙酚对心率有抑制作用，特别在有迷走神经刺激时更加明显；异丙酚对血浆皮质醇的升高有抑制作用。
bjective To compare effects between propofol and sodium pentothal on BP,HR,RPP and cortisol. Method Twenty adult patients with ASA grade I were divided into two groups.Ten of them received propofol induction and maintenance (group 1) while the others received sodium pentothal induction and maintenance after inhaling enflurane (group 2).All patients underwnt extirpation of polyus of vocal cords with self-retaining laryngoscope (SL).And all the changes of BP,HR,RPP were recorded while preinducting,preintubating and postintubating.Meanwhile,the changes of cortisol were also recorded in preoperation and postoperation. Results After using SL,the HR decreased significantly more in group 1 than that in group 2 ( P <0.05).And after operation,the cortisol concentrations in group 2 were significantly higher than those in group 1 ( P <0.01). Conclusion It could be said that propofol inhibited HR,especially in vagotony,i.e.when glottis was stimulated.It also could be showed that propofol would inhibit the increase of cortisol.
出处
《铁道医学》
1998年第3期146-148,共3页
Railway Medical Journal
