摘要
用乙酰胆碱酯酶（ＡＣｈＥ）组织化学方法和体视学测量技术，研究胆碱能纤维在小鼠大脑皮质和海马结构内的分布及增龄变化。结果显示，小鼠大脑皮质和海马结构内ＡＣｈＥ阳性纤维呈不同的板层样分布，老年小鼠（２４月龄）额－顶皮质第Ⅲ、Ⅴ层和海马ＣＡ１、ＣＡ３区分子层及齿状回分子层ＡＣｈＥ阳性纤维密度明显低于成年小鼠（１３月龄）和青年小鼠（３月龄）（Ｐ＜０．０１），后两组间除成年小鼠海马ＣＡ３区分子层纤维密度稍低外，其他各区无显著差异（Ｐ＞０．０５）。结果表明，胆碱能纤维在小鼠大脑皮质和海马结构内的分布具有年龄相关性和区域特异性。
おcetylcholinesterase(AChE) histochemical technique and stereological method,were used to investigate the distribution and agerelated changes of cholinergic filbers in the cerebral cortex and hippocampal in C57BL/6 mouse were investigated. The different laminar distribution patterns of AChEpositive fibers were found in teh cerebral cortex and hippocampal structures.The densities of AChEpositive fibers in the Ⅲ、Ⅳ lavers of the frontoparietal cortex,the molecular layers in CA1、CA3 areas and dentate gyrus of the hippocampal were significantly lower in the aged mice. The results indicate that there are agedependent and regionally distinctive cholinergic fiber distribution of cerebral cortex and hippocampus structures in mice.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1998年第1期36-38,共3页
Chinese Journal of Gerontology
关键词
乙酰胆碱酯酶
大脑皮质
海马
衰老
Acetylcholinesterase\ \ Cerebral cortex\ \ Hippocampus\ \ Aging
