摘要
目的探索糖苷PAL在大鼠胃、肠以及各肠段的吸收动力学特征及吸收部位。方法采用大鼠在体肠灌流吸收实验,以高效液相色谱法测定循环液中药物的浓度。结果同一药物浓度糖苷PAL在全肠段每小时吸收百分率为26.68%,在各肠段即在十二指肠、空肠、结肠和回肠的每小时吸收百分率依次为37.97%、36.10%、25.02%、11.23%,不同的药物浓度:0.80、0.40、0.16 mg.mL-1,在全肠段每小时吸收百分率依次为26.68%、26.12%、25.65%。结论糖苷PAL在胃中不太稳定,在肠道中稳定,吸收也较好,且吸收窗口较长,提示可制成肠溶制剂以供口服吸收。
Objective To explore the absorption kinetics and site of glucosidase PAIr in the gastrointestine in rats. Methods The absorption kinetics and absorption site were investigated in rats using intestine perfusion method. An HPLC method was established to determine the drug concentration in the perfusate. Results The same drug concentration absorption percentage per hour （P%） at the intestine was 26.68%, and the hourly absorption percentages of glucosidase PAL in the duodenum, jejunum, colon, and ileum were aT. 97%, 36. 10%, 2S. 02%, and 11.23%, respectively. Different drug concentrations were 0.80 mg·mL^-1 , 0. 40 mg·mL^-1 , and 0. 16 mg·mL^-1. The absorption percentage per hour at the intestine was 26.68%, 26.12%, and 25.65%, respectively. Conclusion Glucosi dase PAL is moderately absorbed in the stomach, but has no specific absorption site in the intestine. The extensive absorption segments of glucosidase PAL suggest that it can be processed into an enteric-coated formulations.
出处
《中南药学》
CAS
2009年第5期335-337,共3页
Central South Pharmacy
关键词
糖苷PAL
吸收动力学
胃肠道
glycosidase PAL
absorption kinetics
gastrointestine
