摘要
目的观察不同厚度脱细胞猪皮作为自体微粒皮移植覆盖物治疗大面积烧伤的效果。方法随机选择15例大面积深度烧伤患者，其中男性12例，女性3例，年龄35～57岁。烧伤后3-7d行大面积切痂，7例覆盖中厚型脱细胞猪皮，8例覆盖全厚型脱细胞猪皮，将自体微粒皮涂抹于创面，植皮区与供皮区面积比均约为10：1，常规加压包扎。观察猪皮排异变化、微粒皮成活情况及愈后皮肤弹性及外观。结果术后5d脱细胞猪皮与手术创面粘贴良好；中厚型脱细胞猪皮于术后10d、全厚型脱细胞猪皮于术后2周左右脱水干燥；中厚型脱细胞猪皮于术后3周、全厚型脱细胞猪皮于术后1个月左右逐渐分批脱落：脱落后全厚型脱细胞猪皮组创面愈合率达90．3％±2．7％，明显优于中厚型脱细胞猪皮组的68．2％±29％（P〈0.05）：创面愈合后全厚型脱细胞猪皮组瘢痕较轻，外观及弹性优于中厚型脱细胞猪皮组。结论脱细胞猪皮替代异体皮作为微粒皮移植覆盖物．全厚型脱细胞猪皮优于中厚型脱细胞猪皮。
Objective To investigate the effects of different thickness acellular porcine skin as covering microskin on extensive deep bums. Methods Fifteen severely burned patients, male 12, female 3, aged 35 - 57 years, were observed in this study. Eseharotomy of mass extensive bums were performed on day 3 to 7 after burn shock stage and transplanted with different thickness acellular porcine skin as covering microskin. Seven patients treated with moderately-thickness acellular porcine skin and 8 patients treated with that of full-thickness. Autoallergic microskin were covered on the wounds and the acellular porcine skin were perforated into drain and wrapped up. The area ratio of donor skin to recipient was 1 ： 10, The wound was dressed and bandaged with pressure. The rejection of acellular porcine skin, the survival of the microskin grafts and appearance, elasticity of skin were observed. Results The porcine skin was sucked intact in the wound within 5 post-operation days. But it turned to a dry scab after 10 days in moderately-thickness group and about 14 days in full-thickness group. The porcine skin gradually separated from the autogeneic microskin during 3 weeks post-operation in moderately-thickness group, but about 1 month in full-thickness group. The wound healing rate was increased markedly in full-thickness group （90.3 % ± 2.7 %） compared with moderatelythickness group （68.2 % ± 2.9 %, P 〈 0.05）. The appearance and elasticity of skin in full-thickness group was superior to that treated with moderately-thickness acellular porcine skin. Conclusion It is feasible to use acellular porcine skin for substitute of alloskin as covering autogenous microskin in the treatment of extensive deep bums, and the result of treating with full-thickness acellular porcine skin is superior to that with moderately-thickness.
出处
《生物医学工程与临床》
CAS
2009年第3期222-224,共3页
Biomedical Engineering and Clinical Medicine
基金
国家自然科学基金资助项目(30760260)
云南省科技计划项目(2007C247M)
关键词
脱细胞猪皮
烧伤
创面修复
acellular porcine skin
bums
wound repair
