摘要
为了获得粒径为50～100μm的5-氟尿嘧啶／明胶微球（5-Fu／GMs），采用乳化一化学交联法，讨论了5-Fu用量、乳化剂浓度和水／油比等因素对微球平均粒径、载药量及包封率等的影响。结果表明，5-Fu／明胶质量比为0．5，乳化剂浓度为0．5％和水／油相体积比为1／10时，可获得最大的载药量30．1％和包封率90．2％。体外释药性能表明5-氟尿嘧啶明胶微球具有明显的药物缓释作用。
In order to obtain the 50-100μm of 5-fluorouracil/gelatin microspheres（5-Fu/GMs）, emulsion chemical crosslinking method was used. The impacts of 5-Fu contents, surfactant concentration and W/O phase ratio on mean size, drug content, encapsulation efficiency of 5-Fu/GMs were studied. The results showed that 5-Fu/GMs had the drug content 30.1% and the encapsulation efficiency 90.2 %, when 5-Fu/gelatin（w/w）, surfactant concentration and W/O（v/v） respectively were 0.5, 0.5 % and 1/10. In vitro drug release results showed that 5-Fu/GMs could prolong 5-Fu release evidently.
出处
《广东化工》
CAS
2009年第5期117-119,145,共4页
Guangdong Chemical Industry
基金
华中科技大学校科学研究基金(20073017)
关键词
乳化-化学交联法
明胶微球
5-氟尿嘧啶
体外释放
emulsion chemical crosslinking method
gelatin microspheres
5-fluorouracil
in-vitro drug release
