摘要
采用分子印迹技术,以α-甲基丙烯酸为功能单体,合成了对头孢噻肟具有选择结合能力的分子印迹聚合物。将制备的块状聚合物研磨过筛后,运用平衡结合试验研究了头孢噻肟分子印迹聚合物的结合性质。在所研究的浓度范围内,头孢噻肟分子印迹聚合物与相应的非模板聚合物相比,表现出很高的结合容量。底物选择性实验表明:与其他结构相似的药物相比,头孢噻肟分子印迹聚合物对头孢噻肟显示了很强的结合能力。
A kind of molecular imprinted polymer was prepared using cefotaxime as the template molecule, MAA as functional monomer. The bulk polymer was ground up sieved and investigated in equilibrium binding experiment to evaluate the binding characteristic of the cefotaxime - imprinted polymer. The polymer gave much higher binding capacity for cefotaxime than the non - imprinted polymer. The selectivity was evaluated by cefotaxime and other compounds with similar structure. The results showed that the imprinted polymer exhibited high affinity for cefotaxime among the texted compounds .
出处
《中国兽药杂志》
2009年第5期10-13,共4页
Chinese Journal of Veterinary Drug
关键词
头孢噻肟
分子印迹聚合物
cefotaxime
molecular imprinting polymer
