摘要
目的观察思美泰联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)的疗效。方法选择60例ICP患者,随机分为观察组(30例)和对照组(30例)两组。观察组联用思美泰与熊去氧胆酸治疗10d,对照组单用熊去氧胆酸治疗10d。治疗前后分别检测两组患者血清总胆酸(TBA)、总胆红素(TB)、谷丙转氨酶(ALT)和谷草转氨酶(AST),并进行瘙痒评分;评价两组患者妊娠结局。结果两组患者治疗后瘙痒评分、TBA、TB、ALT、AST的水平均较治疗前降低(P<0.01);观察组治疗后瘙痒评分、TBA、TB、ALT、AST的水平较对照组下降明显,差异有显著性意义(P<0.05)。妊娠结局:两组羊水污染率、早产率、新生儿窒息率及新生儿体重差异有统计学意义(P<0.01)。结论思美泰联合熊去氧胆酸是治疗ICP安全有效方法,可改善妊娠预后。
OBJECTIVE To observe the efficacy of S-adenosy-L-methionine（ SAMe） combined with ursodeoxycholic acid（U D CA） in the treatment of intrahepatic cholestasis of pregnancy. METHODS 60 patients were randowly divided into two groups：observe group receiving a combination of UDCA 100mg tid, SAMe 1000mg qd, 5 96 Glucose 500mL/d for ten days and control group receiving UDCA 100mg tid. The symptom of itching and serum biochemical indexes, including TBA, TB, ALT, and AST were observed after 10days, and the pregnancy outcome between the two groups was compared after delivery. RESULTS All the patients had a significant improvement in pruritus and TBA, TB, ALT, and AST（ P 〈 0.01 ）.After 10days, there were significant differences in pruritrs, FBA, AST, ALT, in receiving combination of SAMe and UDCA comparing with receiving UDCA alone （P 〈 0.05）. The incidences of fetal distressa, amniotie fluid pollution and premature delivery are signifiienatly different between the two groups（P 〈 0.01）. CONCLUSION In women with intrahepatic cholestasis of pregnancy,combination of SAMe and UDCA are safe, efficient. The prognosis of pregnancy is improved.
出处
《海峡药学》
2009年第5期118-120,共3页
Strait Pharmaceutical Journal
关键词
妊娠期肝内胆汁淤积症
熊去氧胆酸
思美泰
Intrahepatic Cholestasis of Pregnancy（ICP）
S-adenosy-L-methionin（SAMe）
Ursodeoxycholic acid（UDCA）
