摘要
目的研究动物日本医蛭Hirudo nipponica Whitman的化学成分。方法各种色谱方法进行分离纯化,理化性质和光谱数据鉴定结构。结果从日本医蛭中分离并鉴定了8个化合物,其结构分别为:菜油甾醇(campesterol)(1),十六烷基甘油醚(2),(2S,3S,4E)-4,5-二脱氢十八鞘氨醇二十五烷酸脂肪酰胺(3),1-O-β-D-吡喃葡萄糖基-2-N-(二十二酰基)-E-4,5-二脱氢-3-羟基十八脑苷脂(4),丁二酸(5),次黄嘌呤(6),丙胺酸(7),异亮氨酸(8)。结论以上化合物均为首次从该动物中分离得到。
OBJECTIVE To investigate the chemical constituents from Hirudo nipponica Whitman. METHODS The compounds were isolated and purified by various chromatographic techniques and identi- fied by their physicochemical properties and spectral data. RESULTS Eight compounds were isolated and identified as campesterol （1）, Hexadecyl ethers of glycerol （2）, 2S, 3 S, 4E-4, 5-didehydrooctadecasphingosine pentacosanoic amides （ 3 ）, 1-O- （ β-D-galactopyranosyloxy）-substituted-2-（docosenoylamino） octadec-4-en-3-ol （ 4 ）, succinic acid（5）, hypoxanthine（6）, propylamine（7）, L-isoleucine（8） .CONCLUSION All compounds were obtained from Hedyotis for the first time.
出处
《海峡药学》
2009年第5期75-77,共3页
Strait Pharmaceutical Journal
基金
江苏省中医药局科研项目(H05015)
关键词
日本医蛭
化学成分
Hirudo nipponica Whitman
chemical constituents
