摘要
目的了解再次放疗对鼻咽癌复发病人的治疗价值，并试图分析可能影响再放疗结果的因素。材料与方法１９９１年１月～１９９３年１１月治疗的１１３例复发性鼻咽癌，所有的病人均接受外照射，其中５１例加腔内放疗（１９２Ｉｒ）。结果总的４年生存率、无瘤生存率、局控率分别是５１．２％、４８．３％和４９．９％。分析了复发间隔期对于生存率、局控率和无瘤生存率的关系。观察了２４例病例的初发及复发病灶的细胞凋亡发生情况，发现细胞凋亡数、分裂相数目差异无统计学意义。结论复发性鼻咽癌的再放疗仍是相当有效，尤其是对于复发间隔期大于２年的病例。但在治疗方法上可考虑采用一些非常规的治疗方法。
Purpose To evaluate the value of reirradiation in recurrent nasopharyngeal carcinoma(NPC) and to analyze the factors influencing the retreatment results.Materials and Methods One hundred and thirteen cases of recurrent NPC received radiation therapy during Jan.1991 to Nov.1993 in our hospital. All patients received external beam irradiation,51 of them also received intracavitary brachytherapy(192Ir).Results The overall 4year survival rate,diseasefree survival rate and local control rate were 51.2%,48.3% and 49.9%,respectively.Distant metastasis rate was 18.5%.Two cases with radiation brain necrosis and one case with fistula in hard plate have been observed.The relationship of interval of recurrence and the treatment results,including survival,local control,distant metastasisfree survival was analyzed.The comparisons of histology,apoptosis index(AI) and mitosis index(MI) of initial lesions and recurrent lesions were found insignificant.Conclusion Our data showe the efficacy of reirradiation for treatment of recurrent NPC,especially in those cases with interval of recurrence longer than 2 years.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
1998年第1期37-40,共4页
Chinese Journal of Radiation Oncology
关键词
鼻咽肿瘤
复发性
复发间隔期
放射疗法
Recurrent nasopharyngeal carcinoma(NPC) Reirradiation Interval of recurrence
