摘要
通过滴定法绘制伪三元相图，根据相图优选处方，并初步考察微乳制剂的稳定性、形态粒径和理化性质。用紫外分光光度（Uv-Vis）法测定微乳中多潘立酮的含量。结果表明，制备出的多潘立酮微乳处方是聚氧乙烯氢化蓖麻油（RH-40）／肉豆蔻酸异丙酯（IPM）／多潘立酮／蒸馏水。微乳稳定，透射电镜下呈圆球形，分布均匀，平均粒径12．4nm。在1-50μg／mL浓度范围内，浓度与吸光度的线性关系良好，平均回收率为（99．41±1．17）％，RSD为1．18％（n=5）。多潘立酮微乳应低温（4℃）、避光保存。该处方设计合理，方法可靠。
The optimum formulation was investigated by using titration to prepare the Pseudo-ternary phase diagram, testing the size distribution, stability and physico-chemical property of domperidone microemulsion. Content of domperldone was determined by UV-Vis. The results were as follows. The domperidone microemulsion delivery could be prepared using RH-40/ IPM/domperidone/Water. The stability of domperidone microemulsion was good, and average size was 12.4 nm. Calibration curve was linear in the range of 1μg/mL-50μg/mL the average recovery was （99.41±1.17）%, with RSD of 1.18%（n=5）. Domperidone microemulsion should be stored at low temperature （4°C） and away from light. The formulation is reasonable and the method is accurate.
出处
《西北农业学报》
CAS
CSCD
北大核心
2009年第3期33-37,共5页
Acta Agriculturae Boreali-occidentalis Sinica
关键词
多潘立酮
微乳
(伪)三元相图
质量评价
Domperidone
Mieroemulsion
Pseudo-ternary phase diagram
Quality evaluation
