摘要
目的观察环戊硫酮片治疗干燥综合征干眼的疗效。方法55例干燥综合征干眼患者随机分为对照组(24例)和治疗组(31例),对照组患者接受0.2%卡波姆滴眼液一日3次,每次0.2mg;治疗组患者接受0.2%卡波姆滴眼液一日3次,每次0.2mg和环戊硫酮片一日3次,每次25mg。两组均连续治疗8周。所有入选患者于治疗前和治疗后8周行荧光素角膜活体染色检查、泪膜破裂时间检测(BUT)和泪液分泌检查(Schirmer I test)。结果对照组和治疗组患者在治疗前各泪液检查结果无显著差异(P>0.05),治疗后治疗组患者荧光素角膜活体染色评分分值明显下降(P<0.05),BUT明显延长(P<0.05),且Schirmer I test显示泪液浸湿滤纸的长度明显延长(P<0.05)。治疗组患者与治疗前相比,接受环戊硫酮片治疗后,患者各泪液检查结果显著好转(P<0.01)。结论环戊硫酮片治疗干燥综合征干眼具有良好的临床疗效。
Objective To evaluate the effect of anethole trithione for dry eye in Sjogren＇s syndrome patients. Methods Totally 55 patients （110 eyes） of Sjogren＇s syndrome were enrolled and randomly divided into two groups.The control group （48 eyes of 24 patients） were administrated with 0.2% carbomer （0.2 mg tid）, and the experimental group （62 eyes of 31 patients） were administrated with anethole trithione tablet orally （25 mg tid） combined with carbomer （0.2 mg tid）. Both groups undergone fluorescein staining of cornea, tear film break-up time （BUT） and Schirmer＇s I test before therapy and 8 weeks after. Results There were significant differences （P〈0.05） in the results of fluorescein staining of cornea, BUT and Schirmer I test between two groups after 8 weeks treatment although the two groups were in the same condition at the beginning. There was significant difference （P〈0.01） in experimental group between before therapy and 8 weeks after, while there was no difference in control group （P〉0.05）. Conclusion Anethole trithione is effective for the treatment of dry eye in Sjogren＇s syndrome patients.
出处
《世界临床药物》
CAS
2009年第5期283-286,共4页
World Clinical Drug
关键词
环戊硫酮
干燥综合征
干眼病
anethole trithione
Sjogren＇s syndrome
xerophthalmia
