摘要
目的：观察异种脱钙骨颗粒（ＨＤＧＢ）与天然型无机骨（ＮＮＢ）复合植入下颌骨缺损后的修复过程、成骨能力及免疫排异反应，比较这种复合材料与ＮＮＢ的差异。方法：将１８只中国白兔下颌骨造成缺损，分别植入ＨＤＧＢ／ＮＮＢ与ＮＮＢ，术后不同时间处死取材，进行Ｘ线摄片、组织学光镜及扫描电镜观察。结果：ＨＤＧＢ／ＮＮＢ组出现较强烈的免疫排异反应，新骨形成极少。ＮＮＢ组术后４周已有新骨出现于缺损区，２０周骨缺损完全愈合。结论：免疫排异反应干扰了ＨＤＧＢ的成骨过程；而ＮＮＢ生物相容性好，无免疫排异反应，有较好的传导成骨能力。
Objective:To observe healing process,osteogenic ability and immunologic rejection in the mandibular defect rabbits repaired by combined implantation of heterogenic decalcified granulated bone(HDGB)/natural nonorganic bone(NNB)or NNB implantation,in order to find the difference between these two repairments.Methods:Mandibular defects in Chinese white rabbits were made,and HDGB/NNB compound and NNB were implanted,respectively.At certain periods of time,the rabbits were sacrificed and the specimens were collected and investigated by means of Xray,histomorphology and scanning electron microscopy.Results:In the HDGB/NNB group immunologic rejection was found and without new bone formation;the NNB implantation group had new bone formation in the defect at the 4th week,and complete healing was revealed at 20th week.Conclusion:The immunologic effect might interfered the osteogenetic process of HDGB;and NNB have a good histocompatibility as no immunologic rejection was found.
出处
《中日友好医院学报》
1998年第1期9-12,共4页
Journal of China-Japan Friendship Hospital
基金
中日友好医院青年科研基金
关键词
下颌骨缺损
骨移植
异种移植
外科手术
修复
rabbits
mandible
dentistry,operative
bone transplantation
transplantation,heterotopic
