摘要
选择肝硬变门脉高压病人15例，随机分为两组：长链脂肪乳剂组（n＝8，简称LCT组），中／长链脂肪乳剂组（n＝7，简称MCT组）。两组供氮每天每千克体重0．15～0．2g，非蛋白质热卡为每天每千克体重20～25kcal。LCT组脂肪能源由20％－Intralipid提供，MCT组由20％－LiPofundinMCT／LCT提供。糖脂供能比为2：1。在术前、术后1、4、7天，测定肝、肾功能及胆红素血脂代谢变化。结果表明，术后第1天胆红素明显升高，但MCT组胆红素随后显著下降，I－CT组下降速度慢于MCT组，PM0.05，两组对肝脏功能无明显影响。整个实验过程中甘油三酯无明显变化。提示门脉高压术后PN使用LCT或MCT／LCT乳剂基本上是安全有效的。MCT／LCT乳剂显示出更好的优越性。
Fifteen patients with liver cirrhosis and portal hypertension were studied in a randomlzed perioperation cross-over PN trial of 7 days duration. Their PN regimes was consisted of nonprotein calories (NPC) 20～25 kcal/kg/d and nitrogen 0. 15-0. 20g/kg/d,the lipid energy of group LCT was sup-plied 20%-Intralipid, group MCT was supplied by 20%-Lipofundin MCT/LCT. The PN solution was infused by TNA, 12～16 hrs per day for 7 days. At the pre-OP. PODI. 4. 7d, the following measurements were performed: triglyceride, cholesterol, HDL. LDL.Apo-A. Ppo-B, liver function (ALT. AST. AKP.GGT), bilirubin. The results showed that There were no harmful effection to liver function and bilirubin metabolism in group MCT as compared with group LCT. Those results strongly indicated that it is safty and useful intravenous fat emulsion during one week. MCT maybe an ideal energy source specially for hyperbilirubinemiaa.
出处
《临床外科杂志》
1998年第2期67-69,共3页
Journal of Clinical Surgery
关键词
脂代谢
肝硬变
门脉高压
脂蛋白
肝功
营养支持
Medium chain triglyceride Long chain triglyceride Liver cirrhosis Portalhypertension Liver function Lipid metabolism
