摘要
【目的】研究子宫内膜异位症腹腔镜手术后联合促性腺激素释放激素激动剂（GnRH-a）或米非司酮治疗的效果。【方法】将126例子宫内膜异位症腹腔镜手术后的患者随机分为三组：GnRH-a组39例，米非司酮组46例，术后未用药物者为对照组41例。比较三组患者术后疗效、术后复发、妊娠及用药副反应等情况。【结果]GnRH-a组和米非司酮组的术后有效率、术后复发率差异无显著性（P〉0．05），对照组术后有效率低于其他两组（P〈0．05），复发率显著高于其他两组（P〈0．01），Ⅲ～Ⅳ期患者中，GnRH-a组和米非司酮组妊娠率高于对照组（P〈0．05）。【结论】腹腔镜术后联合GnRH-a或米非司酮治疗子宫内膜异位症较单纯手术缓解率高、复发率低、而且可提高Ⅲ～Ⅳ期患者的妊娠率。
[Objective]To explore the effects of combination of laparoscopy, GnRH-a and mifepristone in the treatment of endometriosis. [Methods]All 126 cases with endometriosis after laparoscopic operation were divided into 3 groups, GnRH-a group（n=39）, mifepristone group（n=46）, and control group（n=41）. The efficacy, relapse rate, pregnancy rate and side effect were compared among three groups. [Results] There was no obvious difference between GnRH a and mifepristone group in efficacy and relapse rate P〉0. 05） . The efficacy in control group was worse than that in the other two groups （P〈0.05）, and the relapse rate in control group was obvious higher than that in the other two groups（P〈0.01）. Among patients of 〉AFS Ⅲ-Ⅳ, the pregnancy rate in control group was lower than that in the other two groups. [Conclusion]The re- lapse rate is lower in laparoscopy combined with medicine group than that in simple operation group for the treatment of endometriosis. Patients of r-AFS Ⅲ-Ⅳtreated with medicine after operation have the increased pregnancy rate.
出处
《医学临床研究》
CAS
2009年第4期617-619,共3页
Journal of Clinical Research
