摘要
目的研究中药胃安素对慢性萎缩性胃炎及癌前病变的防治作用．方法临床研究，以市售维酶素为对照药，采用随机双盲法，共观察慢性萎缩性胃炎６０例，通过内镜观察、胃粘膜病理检查及对尿１７羟、血流变、血清Ｈｐ抗体、胃粘膜尿素酶、ＳＯＤ等指标的检测，观察中药胃安素对慢性萎缩性胃炎及胃癌前病变的治疗作用．实验研究，采用２月龄Ｗｉｓｔａｒ大鼠，以主动免疫、去氧胆酸钠自由饮用、寒凉胆汁灌胃、饥饱失常的综合法，造成萎缩性胃炎中医辩证为脾肾两虚型动物模型，造模同时进行预防实验．造模成功后进行治疗实验，５０ｄ后处死动物，进行胃粘膜病理检查及各项相关指标的检测（对照药为三九胃泰和维酶素）．结果临床研究结果显示，胃安素及维酶素对慢性萎缩性胃炎及癌前病变的综合疗效分别为：９６８％和７５８％，经统计学处理，Ｐ＜００５．实验研究结果显示，胃安素对慢性萎缩性胃炎大鼠的预防及治疗作用，明显优于三九胃泰及维酶素组（Ｐ＜００５）．
IM To evaluate the therapeutic effect of Wei An Su Capsule (WASC) in the treatment of chronic atrophic gastritis (CAG).METHODS Sixty cases of CAG diagnosed endoscopically and histopathologically were divided into two groups. Group A (31 cases) was treated with WASC, and group B (29 cases) with Wei Mei Su Tablet. Gastric mucosal histomorphology was observed under endoscope, light and electron microscope. The experimental chronic atrophic gastritis model with Spleen and Kidney deficiency in male Wistar rats was established successfully by the method of multielementary damages, such as active immunity, sodium deoxychlate and cold bile and irregular feeding were administered, the preventiven experiment was carried out simultareously. On the 50th day, all animals were killed, and gastric mucosa were observed.RESULTS The preventive and therapeutic effect in Group A was better than in Group B. The total effectiveness rate of Group A was 967%, and Group B 758%, difference being significant (P<005). Better effects were also achieved in relieving symptoms, reducing active inflammation of gastric mucosa, and recovering the adrenocostical function in group A than in group B. CONCLUSION WASC had preventive and therapeutic effect for chronic atrophic gastritis.
关键词
萎缩性胃炎
中医药疗法
胃安素
gastritis atrophic/zhong yi yao liao fa
reinforcing spleen & kidney
astragalus membranaceus/therapeutic use
atractylodes macrocephala/therapeutic use
rehmannia glutinosa/therapeutic use
