摘要
目的：探讨血浆心肌肌钙蛋白T（TnT）在烧伤后早期心肌损伤时的变化特点及其诊断学意义。方法：采用双抗夹心酶联免疫吸附法（ELISA）动态观察30％体表面积Ⅲ度烫伤大鼠伤后1、3、6、12和24小时血浆TnT水平及心肌组织病理学变化。结果：大鼠伤后3小时血浆TnT水平［（0．58土0．14）μg／L］较正常对照［（0．14士0．04）μg／L〕显著升高（P＜0.05），12小时达峰值［（3.53士0.69）μg／L，P＜0．o1〕，约为正常参考值的20倍。伤后24小时TnT水平〔（1．55士0．37）μg／L〕虽有所下降，但仍显著高于伤前（P＜0．01）。血浆TnT水平与心肌损伤程度相关。结论：血浆TnT可作为诊断烧伤后心肌损伤敏感而特异的指标。
Objective:To investigate the significance of changes in plasma cardiac troponin T(TnT)contents and its diagnostic value for early myocardial injury following major burns. Methods: Wistar ratswere subjected to 30% total body surface area Ⅲ scald injury. Plasma TnT content was measured byenzyme- linked immunosorbent assay method and histologic changes in myocardium were examined at1, 3, 6, 12 and 24 hours postburn. Results: TnT contents increased rapidly at 3 hours 〔(0. 58± 0. 14)μg/L 〕 and reached maximum at 12 hours postburn 〔(3. 53± 0. 69)μg/L,P<0. 01〕,being 20 fold of normalcontrols 〔 (0. 14 ± 0. 04 )μg/L〕. TnT contents lowered at 24 hours postburn 〔 (1. 55 ± 0. 37) μg/L〕, butstill higher than that of normal controls (P<0. 01 ). Additionally,plasma TnT contents were correlatedwith the seventy of myocardial injury. Conclusions:It is suggested that TnT may be a useful marker forthe diagnosis of myocardial injury after thermal injury.
出处
《中国危重病急救医学》
CAS
CSCD
1998年第3期145-147,共3页
Chinese Critical Care Medicine
基金
全军八五攻关课题
