摘要
目的：研究血浆可溶性P选择素（PPS）在急性出血坏死型胰腺炎并发肺损伤大鼠模型中对肺损伤的诊断价值。方法：将5％牛磺酸胆酸钠注入SD大鼠胆胰管内，制成急性出血坏死型胰腺炎并发肺损伤的动物模型。用放射免疫方法测定PPS在模型制成后的1、3和6小时的变化。结果：经病理证实在注入牛磺酸胆酸钠后1小时，成功建立肺损伤模型；且PPS在制成大鼠肺损伤模型后的含量明显升高，并在制成肺损伤模型后的3小时达到高峰（14．69士5．55）μg／L。结论：血浆可溶性P选择素的升高对急性肺损伤的诊断有确切意义。
Objective:To evaluate the diagnostic value of plasma soluble P - selectin (PPS) in lunginjury in rats with acute hemorrhagic necrotizing pancreatitis. Methods: Acute hemorrhagic necrotizingpancreatitis in rats was induced by injecting 5% sodium taurocholate into common binary - pancreaticduct. PPS was measured by radioimmunoassay at 1, 3,and 6 hours following acute hemorrhagic necrotizing pancreatitis. Results:Lung injury in rats was confirmed at l hour after 5% sodium taurocholate injection,and PPS levels were markedly elevated,peaking at 3 hours after injury 〔(14. 69± 5. 55)μg/L〕.Conclusions:The results suggest that PPS is a useful marker for the diagnosis of lung injury followingacute hemorrhagic necrotizing pancreatitis.
出处
《中国危重病急救医学》
CSCD
1998年第3期142-144,共3页
Chinese Critical Care Medicine
