摘要
用天水地区大骨节病区粮及病区水土中提取的富里酸（ＦＡ）饲养的６周龄Ｗｉｓｔａｒ大鼠，以非病区粮及非病区水土中提取的ＦＡ做对照，在相应各组饮水中加入Ｎａ２ＳｅＯ３（０．２ＰＰｍ）做为补硒组，６周后取腓肠肌、胫骨前肌，进行ＳＤＨ酶－Ａｃｈｅ酶组织化学复合染色，显示红、白、中间肌各型肌纤维及运动终板。结果表明，病区粮、病区ＦＡ单一或复合因素与对照组比较，各型肌纤维组间均径值明显低下，其ＳＤＨ酶活性明显降低，证明可使骨骼肌明显萎缩，运动终板也出现萎缩，则补硒后可见有明显抗骨骼肌萎缩作用。
Fuli acid (FA) extracted from the guain and water of Tianshui KaschinBeck disease region was dissolved in water which was given to Wistar rats of six weeks old,and FA out of nonKascinBeck disease area was given to rats in the contral group.For the rats of all groups,Na 2SeO 3 was added to the drinking water(0 2PPM)for replenishing selenium.Six weeks later,skeletal muscles such as gastrocnemius and tibialis anterior were taken out for SDHaseAchEase histochemical compoud staining.The observation showed that the mean diameters of all kinds of skeletal muscles of KaschinBeck disease group were smaller than that of the contral group.The activity of SDHase was obviously weaker than that of contral group.It can be infrred that FA may cause atrophy of skeletal muscles and motor nerve endings,and selenium appeared to have antiatrophy effect.
关键词
大骨节病区
富里酸
亚硒酸钠
骨骼肌
运动终板
grain of KaschinBeck disease reion fuli acid,sodium selenite skeletal muscles AchESDHase.
