期刊文献+

200例次丙戊酸血药浓度监测结果分析 被引量:6

暂未订购
导出
摘要 目的通过监测丙戊酸血药浓度,为临床合理用药提供参考依据。方法采用荧光偏振免疫法测定丙戊酸血药浓度,对200例次血药浓度监测结果进行比较分析。结果丙戊酸测定值在有效治疗浓度范围内(50~100mg·mL-1)的有113例次,占56.5%;低于治疗浓度范围下限(<50mg·mL-1)的有63例次,占31.5%;高于治疗浓度范围上限(>100mg·mL-1)的24例,占12%。结论丙戊酸血药浓度监测仍然十分必要。
出处 《西北药学杂志》 CAS 2009年第3期210-211,共2页 Northwest Pharmaceutical Journal
  • 相关文献

参考文献5

二级参考文献49

  • 1陈锦珊,杜青云,黄惠丽.丙戊酸钠治疗小儿癫痫血药浓度监测与合理用药[J].中国医院药学杂志,2004,24(7):424-426. 被引量:32
  • 2Farber NB, Jiang XP, Heinkel C, et al. Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity [J]. Mol Psychiatry, 2002, 7(7): 726-733.
  • 3Angehagen M, Ben-Menachem E, Ronnback L, et al.Novel mechanisms of action of three antiepileptic drugs,vigabatrin, tiagabine, and topiramate[J]. Neurochem Res,2003, 28(2):333-340.
  • 4Rose MA, Kam PC. Gabapentin: pharmacology and its use in pain management[J]. Anaesthesia, 2002, 57(5):451-462.
  • 5McLean MJ. Clinical pharmacokinetics of gabapentin[J].Neurology, 1994, 44(6 Suppl 5): S17-S22.
  • 6Wu WN, Heebner JB, Streeter A J, et al. Evaluation of the absorption, excretion, pharrnacokinetics and metabolism of anticonvulsant topiramate in healthy men [J].Pharm Res, 1994, 11(10 Suppl): S336.
  • 7Browne TR. Pharmacokinetics of antiepileptic drugs[J].Neurology, 1998, 51(5 Suppl 4):S2-S7.
  • 8Perucca E. The clinical pharmacokinetics of the new antiepileptic drugs[J]. Epilepsia, 1999, 40(Suppl 9):S7-S13.
  • 9Perucca E, Johannessen SI. The ideal pharmacokinetic properties of an antiepileptic drug: how close does leve tiracetam come[J]? Epileptic Disord, 2003, 5(Suppl 1):S17-S26.
  • 10Langtry HD, Gillis JC, Davis R. Topiramate. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of epilepsy[J].Drugs, 1997, 54(5): 752-773.

共引文献56

同被引文献58

引证文献6

二级引证文献27

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部