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阿魏酸钠对急性缺血性肾功能衰竭大鼠血浆ET、NO水平的影响 被引量:5

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摘要 目的:探讨阿魏酸钠对大鼠急性缺血性肾功能衰竭(IARF)的保护作用及可能的作用机制。方法:采用同时钳夹双侧肾动脉30 min,再灌注18 h建立大鼠IARF动物模型,将实验动物分为假手术组、造模组及阿魏酸钠预防组。观察各组大鼠血肌酐(Scr)、血清尿素氮(BUN)、血清一氧化氮(NO)、血清内皮素(ET)及肾脏病理的变化。结果:与造模组比较,阿魏酸钠预防组的Scr、BUN、ET水平明显下降(P<0.05),血清NO明显升高(P<0.05)。结论:阿魏酸钠能减轻大鼠IARF的肾脏损害,对肾脏有保护作用,其机制可能与调节ET及NO的浓度有关。
出处 《山东中医杂志》 2009年第5期341-342,共2页 Shandong Journal of Traditional Chinese Medicine
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  • 1张萱,韩丽姝,徐晋,齐玲,张宝东,葛春芳,刘强.肾缺血再灌注损伤和丹参的保护作用的实验研究[J].解剖科学进展,1996,2(3):269-272. 被引量:27
  • 2Rice JC, Spence JS,Yetman DL,et al.Motocyte chemoattractant protein- 1 expression conelates with motocyte infiltration in the post- ischemic kidney[J]. Ren Fail,2002,24(6) : 7{13- 723.
  • 3Leonard MO,Hannan K, Burne MJ, et al. 15 - Epi - 16 -(fluorophenoxy) - lipoxinA (4) - methyl - methyl - ester,synthetic analogue of 15- epi- lipoxinA(4),is a protective in experimental acute ischemic renal failure [ J ]. J Am Sol Nephrol,2002,13(6) : 1657 - 1662.
  • 4Deng J,Kohda Y,Chiao H, et al. Interleukin- 10 inhibits ischemic and cisplatin - induced acute renal injury[ J ]. Kidney Int,2001,60(6) :2118 - 2128.
  • 5Pallet MS, Hoidal JR, Ferris TF. Oxygen free radicals in ischemic acute renal failure in the rat[J]. J Clin Invest, 1984,74(4) : 1156 - 1164.
  • 6Riera M,Torras J,Cruzako JM,et al.The enhancement of endogenous cAMP with pituitary adenylates polypepyide protects rat kidney against ischemia through the modulation of inflammatory response[J] .Transplantation ,2001,72(7) : 1217 - 1223.
  • 7Had M,Nonnan J,Saba SR, et al. Role of IL- 1 in ischemic reperfusion injury[J]. J Am Sol Nephrol, 1998,9(4) : 614 -619.
  • 8Furuichi K,Wada T,Twata Y,et al.Administration of FR167653,a new anti - inflammatory compound, prevent renal ischemia/reperfusion injury in mice[J].Nephrol Dial Transplant, 2002,17(3):399-407.
  • 9Maleft DW, Figdor GG, Huijbens R, et al. Effects of interleukin- 13 on phenotype, cytokine production, and cytotoxic function of human monocytes, comparison with IL- 4 and modulation by IFN - gamma IL- 10[J]. J Immunol, 1993, 151 (11):6370 - 6381.
  • 10Minty A,Chalon P, Derocq JM,et al. Interleukin- 13 is a new regulating inflammatory and response [ J ]. Nature, 1993, 362(6417) :248 - 250.

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