摘要
药物引起的免疫介导性肝损伤一般为特异质性，相对较少，但往往较为严重。一些药物性肝损伤（DIU）患者具有自身免疫性肝炎的临床特征。药物在肝内代谢过程中产生的反应性中间代谢物在免疫介导的DILI发病过程中发挥重要作用。
Drug-induced immune-mediated hepatic injury is a relatively rare but potentially severe form of liver injury that arises in an idiosyncratic manner. Some patients with drug-induced liver injury （DILI） have clinical features of autoimmune hepatitis. Reactive intermediate metabolites derived from the drug during intrahepatic metabolism appear to play a crucial role in eliciting some forms of immune-mediated DILI.
出处
《胃肠病学》
2009年第4期221-224,共4页
Chinese Journal of Gastroenterology
关键词
肝炎
慢性
药物性
肝炎
自身免疫性
自身抗体
Hepatitis, Chronic, Drug-Induced
Hepatitis, Autoimmune
Autoantibodies
