摘要
目的:评价紫杉醇脂质体联合顺铂、氟尿嘧啶(PCF方案)一线治疗晚期胃癌的临床疗效和毒副反应。方法:PCF方案一线治疗42例晚期胃癌的具体用法:紫杉醇脂质体175mg/m2,第1天静滴90min;顺铂75mg/m2,第1天静滴;亚叶酸钙400mg/m2,第1天滴注2h;氟尿嘧啶2.6g/m2,亚叶酸钙滴注结束后立即持续泵入46h。21天为1周期,每2周期按RE-SIST标准评价疗效,所有患者至少接受2周期化疗。结果:42例患者共接受192个周期的化疗,所有患者均可评价疗效。完全缓解3例(7.1%),部分缓解20例(47.6%),稳定12例(28.6%),进展7例,总有效率为54.8%,中位进展时间(TTP)6.5个月,中位生存时间(MST)13.9个月。常见的不良反应为血液学毒性,胃肠反应、肌肉酸痛、外周神经毒性较轻,以Ⅰ、Ⅱ级为主。10例(23.8%)发生Ⅲ～Ⅳ级粒细胞减少,伴发热1例(2.4%);Ⅲ级恶心呕吐反应4例(9.5%),Ⅲ级肌肉酸痛3例(7.1%),Ⅲ级外周神经毒性2例(4.7%),无化疗相关性死亡病例。结论:紫杉醇脂质体联合顺铂、氟尿嘧啶(PCF方案)一线治疗晚期胃癌疗效确切,不良反应轻,值得临床推广应用。
Objective：The prognosis of advanced gastric cancer（AGC） is poor,no standard chemotherapy regimens for AGC are available.The study was to evaluate the efficacy and toxicity of paclitaxel liposome plus cisplatin and 5-fluorouracil（PCF regimen） as first-line chemotherapy for AGC patients.Methods：Forty-two patients with pathologically confirmed AGC entered into the study.On day 1,patients were infused with 175 mg/m^2 paclitaxel liposome over 3h,infused with 75mg/m2 cispltin,infused with 400mg/m^2 leucovorin（CF） over 2h,followed by 46h infusion of 5-fluorouracil at 2 600mg/m^2.The cycle was repeated every three weeks.Treatment efficacy was evaluated every two cycles based on the RESIST standard.All patients received at least two cycles of therapy.Results：Patients received a total of 192 cycles of treatment,and all were evaluable for efficacy and toxicity.The overall response rate was 54.8%,3 cases（7.1%） achieved complete responses（CR）,20（47.6%）achieved partial responses（PR）,12（28.6%）had stable disease（SD）,and 7 had progression disease（PD）.The median time to progression（TTP） was 6.5 months and the median survival time（MST） was 13.9months.Hematologic toxicity included 10 cases（23.8%） of grade 3-4 neutropenia,one of which was accompanied with fever,the main non-hematologic toxicity included 4 cases of grade of 3 nausea and vomiting（9.5%）,3 cases of grade of 3 myalgia（7.1%）,and 2 cases of grade of 3 peripheral neuropathy（4.7%）,No occurrence of treatment related deaths.Conclusion：PCF regimen is effective and well tolerated as first-line chemotherapy for AGC patients.
出处
《临床肿瘤学杂志》
CAS
2009年第4期332-335,共4页
Chinese Clinical Oncology
关键词
晚期胃癌
化学疗法
紫杉醇脂质体
顺铂
氟尿嘧啶
Advanced gastric cancer
Chemotherapy
Paclitaxel liposome
Cisplatin
5-fluorouacil
