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预测大剂量甲氨蝶呤化疗消除相药物的排泄 被引量：2

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摘要 大剂量甲氨蝶呤（MTX）化疗是目前治疗小儿急性淋巴细胞白血病（ALL）常用的方法。大剂量MTX化疗后药物消除相的排泄在不同个体和不同疗程间差异都较大。每6h检测MTX消除相血药浓度1次可以满足甲酰四氢叶酸钙解救的需要，但是频繁采血和检测，不仅患儿痛苦、花费较高，而且目前的国情也很难在临床常规开展。我们对大剂量MTX化疗后消除相药物排泄的预测进行了一些研究，报道如下。
作者 华瑛 赵卫红 卢新天 杨丽华 卢炜
机构地区 北京大学第一医院儿科 南方医科大学珠江医院儿科 北京大学医学部药学院药剂教研室
出处 《中华血液学杂志》 CAS CSCD 北大核心 2009年第5期343-345,共3页 Chinese Journal of Hematology
关键词 大剂量甲氨蝶呤 药物排泄 化疗后 预测 急性淋巴细胞白血病 甲酰四氢叶酸钙 MTX 血药浓度
分类号 R686 [医药卫生—骨科学]
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共引文献516

同被引文献33

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中华血液学杂志
2009年 第5期

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