摘要
目的探讨Endoglin在卵巢上皮性肿瘤血管生成中的意义。方法采用免疫组织化学方法,对本院2000年12月至2003年12月手术切除的70例卵巢上皮肿瘤标本分别标记CD34和Endoglin,并分别进行微血管密度(microvessel density,MVD)计数。结果CD34标记的MVD在良性和恶性卵巢上皮性肿瘤间无统计学差异(P>0.05),而Endoglin标记的MVD在良性和恶性肿瘤间差异有统计学意义(P<0.05);恶性卵巢上皮性肿瘤临床Ⅰ～Ⅱ期CD34和Endoglin标记的MVD均高于Ⅲ～Ⅳ期;CD34标记的MVD在恶性卵巢上皮性肿瘤病理分级Ⅰ、Ⅱ、Ⅲ级间无统计学差异(P>0.05),而病理分级Ⅲ级Endoglin标记的MVD明显高于Ⅰ～Ⅱ级。结论Endoglin标记计数的MVD优于CD34、CD31和VonWille-brand因子等标记的MVD,可作为肿瘤血管生成状态的评价指标。
Objective To investigate the significance of endoglin in the angiogenesis of ovarian carcinoma. Methods Immunohistochemical assay was used to investigate 70 tissue samples of pathologically identified epithelial ovarian tumor （including 31 specimen of benign and 39 of malignant） from December 2000 to December 2003 in our department using monoclonal antibodies against CD34 and endoglin. Microvessels density （MVD） was counted by experienced pathologists. Results No significant difference of MVD for CD34 was observed in the ovarian eystadenoma and ovarian carcinoma. In contrast, an increment of MVD for endoglin from low-grade to high-grade dysplasia and that from earlier stage to later stage was statistically significant. Conclusion Endoglin may be a valuable marker for assessing neovascularization in the process of ovarian carcinoma development and for predicting the risk of ovarian carcinoma development.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2009年第10期945-947,共3页
Journal of Third Military Medical University
基金
国家自然科学基金(30271360
30600673)~~
