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体重指数对10年累积高血压发病危险的预测作用 被引量:38

Association between body mass index and ten-year-accumulative-risk of hypertension
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摘要 目的探讨北京地区队列人群基线(1992年)BMI水平及10年(1992-2002年)BMI水平的变化与高血压发生的关系。方法采用前瞻性队列研究的方法,于1992年对北京大学社区和首都钢铁公司地区35~64岁人群进行基线心血管病危险因素调查,并持续10年对心血管病的发病情况进行随访。在2002年对相同人群再次进行了危险因素调查。两次调查资料完整,且对基线无高血压的2115人进行分析。结果调查的35—64岁人群10年高血压累积发病率为34.8%。随着基线BMI水平的增加,10年后高血压的累积发病率呈增加趋势(P〈0.001),男女两性的变化趋势一致。在45~54岁组和55。64岁组,随着基线BMI水平的增加,10年高血压的累积发病率也呈线性增加趋势(P〈0.05)。多因素logistic回归分析显示,BMI≥28kg/m^2组的高血压发病危险是BMI〈24kg/m^2组的3.6倍;10年BMI水平每增加1kg/m^2,累积发生高血压的危险增加17.5%。1992年和2002年BMI均正常者中有22.0%的人发生高血压,1992年和2002年BMI均判为肥胖者中有56.3%的人发生高血压。结论BMI是高血压发病的一个独立危险因素,随着基线BMI水平的增加高血压的发病危险也增加。 Objective To explore the association between body mass index (BMI) and ten-year accumulative risk of hypertension. Methods A prospective study of relationship between blood pressure and other traditional risk factors was carried out in a cohort with 2115 people aged 35-64 years old involved, in 1992 and 2002. The association between baseline BMI level and a ten-year accumulative risk of hypertension was analyzed. Results The ten-year accumulative incidence rate of hypertension was 34.8%, and increased with the elevated baseline BMI level in both genders (P〈0.001). Similar changing trends were observed in both age groups of 45-54 year and 55-64 year olds (P〈 0.05). Multivariable OR (95%CI) of accumulative incident hypertension in the highest BMI tertile (≥28 kg/m^2) was 3.569 higher (2.559 to 4.977) when compared to the lowest ( 〈24 kg/m^2). The ten-year accumulative risk of hypertension increased 17.5% with elevation of baseline BMI level by 1 kg/m^2. The ten-year accumulative incidence rate of hypertension was 22.0% in the subjects with normal BMI and 56.3% in those with obesity, both in 1992 and 2002. Conclusion BMI appeared to be an independent risk factor for hypertension, and the risk of incident hypertension increased with elevated BMI level.
出处 《中华流行病学杂志》 CAS CSCD 北大核心 2009年第5期435-438,共4页 Chinese Journal of Epidemiology
基金 北京市自然科学基金(7082019)
关键词 高血压 心血管疾病 体重指数 流行病学 Hypertension Cardiovascular disease Body mass index Epidemiology
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参考文献18

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