摘要
旨在筛选如意巴布剂中透皮促进剂的种类和用量。采有体外扩散池法，以如意巴布剂中小檗碱的经皮渗透量为指标，用ＨＰＬＣ法定量检测透过的小檗碱。结果表明，与不含促透剂样品比较，３％氮酮与１０％丙二醇合用可显著提高如意巴布剂中小檗碱的经皮渗透（Ｐ＜０．０１），７２ｈ中小檗碱的累积透过量增加了１６８．３％，经皮渗透速率提高了１．６３倍。说明３％氮酮与１０％丙二醇合用为如意巴布剂中最佳透皮促进剂，其中小檗碱的经皮渗透符合一级速率过程。
To screen the best kinds and doses of enhancers for Ruyi Patcher,the effect of azonc(A) and propanediol(P) on the permeation of berberine(BR) from Ruyi Patcher in vitro was studied using improved Franz diffuse cells and the permeated berberine was determined by HPLC.The result showed that 3% of A in combination with 10% of P had synergistic effect,which helped enhance the skin permeation of BR significantly(P<0.01).Therefore,a combination of 3% A and 10% P is the best enhancer for Ruyi Patcher and the penetration process of BR could be described by oneorder kinetics.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1998年第2期90-91,共2页
China Journal of Chinese Materia Medica
